MeltingCORE
About me
I blog whatever comes to mind. Music, fashion, art, and space are big things. I highly suggest you push the random post button, there's some cool stuff on here.
I also post my artwork and my comic Crystal. Crystal is a comic that brings awareness to the suffering that Schizophrenia causes. My experience with Schizophrenia is shared as well, along with tips from my therapist to *hopefully* help others deal with this serious illness.

///FEEL FREE TO ASK ME QUESTIONS ABOUT THE ILLNESS OR FOR ADVICE IF YOUR DEALING WITH SIMILAR ISSUES.///

My mind calls me the Reactor Girl. Reality says I am Emily. Melting and fusing. I have jumped into core 208 - my mind’s boiling point. Calorification is imminent. I want to be white hot energy. This incinerator’s seething grasp is an extravaganza. My thoughts are drowning in rustic pipelines and wire nebulae. I am synthesizing a beautiful and chaotic world. A universe unknown - only able to be seen through my artwork.

(Source: puritychalice)

I am very sad to report that Carla Laemmle, one of our last direct links to the world of silent cinema, has passed away at 104.

Born in 1909 with the given name Rebecca, she later changed her name to Carla. The niece of Universal Studios founder Carl Laemmle, she danced as the prima ballerina in The Phantom of the Opera (1925) and spoke the first line of dialogue in the first sound horror film, Dracula (1931). May she rest in peace and be forever remembered.

(Source: nitratediva)

thehijabilolita:

gnzg:

Been a while since I’ve posted here heh

I caught site of tumblr user thehijabilolita two nights ago and well, she was just too cute patoots that I had to draw her

gnzg
drew this lovely piece of me! It’s so cute and I am really fond of it thank you!

neurosciencestuff:

Experimental Cancer Drug Reverses Schizophrenia in Adolescent Mice

Johns Hopkins researchers say that an experimental anticancer compound appears to have reversed behaviors associated with schizophrenia and restored some lost brain cell function in adolescent mice with a rodent version of the devastating mental illness.

The drug is one of a class of compounds known as PAK inhibitors, which have been shown in animal experiments to confer some protection from brain damage due to Fragile X syndrome, an inherited disease in humans marked by mental retardation. There also is some evidence, experts say, suggesting PAK inhibitors could be used to treat Alzheimer’s disease. And because the PAK protein itself can initiate cancer and cell growth, PAK inhibitors have also been tested for cancer.

In the new Johns Hopkins-led study, reported online March 31 in the Proceedings of the National Academy of Sciences, the researchers found that the compound, called FRAX486, appears to halt an out-of-control biological “pruning” process in the schizophrenic brain during which important neural connections are unnecessarily destroyed.
Working with mice that mimic the pathological progression of schizophrenia and related disorders, the researchers were able to partially restore disabled neurons so they could connect to other nerve cells.

The Johns Hopkins team says the findings in teenage mice are an especially promising step in efforts to develop better therapies for schizophrenia in humans, because schizophrenia symptoms typically appear in late adolescence and early adulthood.

“By using this compound to block excess pruning in adolescent mice, we also normalized the behavior deficit,” says study leader Akira Sawa, M.D., Ph.D., a professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine. “That we could intervene in adolescence and still make a difference in restoring brain function in these mice is intriguing.”

For the mouse experiments, Sawa and his colleagues chemically turned down the expression of a gene known as Disrupted-in-Schizophrenia 1 (DISC1), whose protein appears to regulate the fate of neurons in the cerebral cortex responsible for “higher-order” functions, like information processing.

In studies of rodent brain cells, the researchers found that a DISC1 deficit caused deterioration of vital parts of the neuron called spines, which help neurons communicate with one another.

Reduced amounts of DISC1 protein also impact the development of a protein called Kalirin-7 (KAL7), which is needed to regulate another protein called Rac1. Without enough DISC1, KAL7 can’t adequately control Rac1 production and the development of neuronal spines. Excess Rac1 apparently erases spines and leads to excess PAK in the mice.

By using FRAX486 to reduce the activity of PAK, the researchers were able to protect against the deterioration of the spines caused by too little DISC1, halting the process. This normalized the excess pruning and resulted in the restoration of missing spines. They were able to see this by peering into the brains of the mice with DISC1 mutations on the 35th and 60th day of their lives, the equivalent of adolescence and young adulthood.

Sawa, who is also director of the Johns Hopkins Schizophrenia Center, cautions that it has not yet been shown that PAK is elevated in the brains of people with schizophrenia. Thus, he says, it is important to validate these results by determining whether this haywire PAK cascade is also occurring in humans.

In the mice, the researchers also found that their behavior improved when PAK inhibitors were used. The mice were tested for their reaction to noises. There is a neuropsychiatric phenomenon in which any organism will react less to a strong, startling sound when they have first been primed by hearing a weaker one. In schizophrenia, the first noise makes no impact on the reaction to the second one.

The mice in the study showed improvements in their reactions after being treated with the PAK inhibitor. The drug was given in small doses and appeared to be safe for the animals.

“Drugs aimed at treating a disease should be able to reverse an already existing defect as well as block future damage,” Sawa says. “This compound has the potential to do both.”

(Image: iStockphoto)

apofiss:

'nature walk', a continuation of 'walk series'!

ayumihamasaki:

Love songs era singles
2010

tags:
#she
Life goes on

So I mentioned in an earlier post that my family is having money issues, but I’m having a good attitude about it. Still doing that. We’re almost out of it, just a few more weeks. I’ve had to cut my pills in half to make them last. Thankfully I haven’t had any real problems except some illogical anger and paranoia, but its summer and I can stay in my room. I did go ahead and decide not to take my second math class because we can’t afford it and I’d rather take it next summer anyways. *shrugs*

-MeltingCORE

[source needed]

(Source: suitlessease)

On touch (question for you all)

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japanwilltakeyourbreathaway:

Sakura jelly.

tags:
#my art

a new wip. trying something funky with the inking here.

Anonymous sent:

So I was diagnosed with severe depression and severe anxiety last year and I was put on fluoxetine for it soon after (I'm still on it now). Recently I have been feeling depressed again, anxious and as though everyone hates me and people are out to get me. I'm isolating myself again, I'm losing my sense of self worth and I'm not coping well at school. I'm starting to also feel like I'm being watched/recorded by something/someone. I don't know what to do because people think I'm doing well..? help

I know it’s hard, but you really need to reach out to someone as those symptoms are quite troubling. You can’t hide your symptoms because you’ll just deteriorate until you’re sent to the mental hospital. Cause something like mental illness doesn’t get better on its own and hiding it just makes it worse. Trust me - I would know. A few years ago I didn’t tell my parents I was hearing voices again until one of my journals was covered in my own blood and that got me sent to the hospital for a while. You don’t have to broadcast your issues to the world but do you think you could tell your parents or doctors? Especially your doctors. They’re there to help you so don’t be afraid that they’ll be disappointed or something. Relapses are normal with mentally ill people and they know that. If you need anything else feel free to message me again, lovely. c:

PS: I told someone else this recently, but I think it’d be a good idea to stay home from school until you feel better. No reason to be at school, especially if it’s making things worse.

-MeltingCORE